ATP-sensitive K channel channel/enzyme multimer: Metabolic gating in the heart
نویسندگان
چکیده
منابع مشابه
Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP
The beta cell KATP channel is an octameric complex of four pore-forming subunits (Kir6.2) and four regulatory subunits (SUR1). A truncated isoform of Kir6.2 (Kir6.2DeltaC26), which expresses independently of SUR1, shows intrinsic ATP sensitivity, suggesting that this subunit is primarily responsible for mediating ATP inhibition. We show here that mutation of C166, which lies at the cytosolic en...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2005
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2005.02.022